Ropivacaine hydrochloride, CAS number 132112-35-7

• Chemical Name: Ropivacaine hydrochloride
• CAS Number: 132112-35-7
• Molecular Formula: C13H21NO3·HCl
• Classification: Amino amide local anesthetic
• Primary Use:
  • Local anesthesia for pain management during surgical procedures
  • Analgesic properties for pain relief

Applications:

1. Delayed Cerebral Vasospasm (DCVS) in Subarachnoid Hemorrhage (SAH):

   • RP-HCl encapsulated in nanoliposomes (NLPs) has been studied for its potential to improve neurological function, reduce vasospasm, and mitigate endothelial cell apoptosis.
   • While promising in animal models, further clinical trials are needed for human application.

2. Veterinary Use (Ophthalmology):

   • RP-HCl has been shown to reduce corneal sensitivity in horses when applied topically.
   • It was effective in reducing sensitivity alongside lidocaine without short-term adverse effects, showing potential in veterinary ophthalmology.

Precautions:

• Dosing: Correct dosing is critical to avoid toxicity.
• Monitoring: Monitor for allergic reactions and systemic toxicity.
• Contraindications: Hypersensitivity to ropivacaine or its components.
• Intravascular Injection: Caution is needed to avoid inadvertent intravascular injection, which could lead to systemic toxicity.